TYKERB 250MG TABLET ( Lapatinib ) - Buy TYKERB 250MG TABLET Online at best Price in India-apple pharmaceuticals

Tykerb 250mg

Tykerb 250mg tablets are classified as anti-cancer agent, which is orally active drug used for treating breast cancer Chemically classified as quinazoline with strong anti-cancer effect and the tablet Tykerb  250mg is a synthetic oral tablet Normally targeted therapy or tyrosine kinase inhibitor drugs are capable of increasing the plasma amino transferase levels which may lead to liver injury, the main ingredient which is used as lapatinib. Tykerbtablets are classified as;
1. Tyrosine kinase prohibitor
2. Stop the HER2/neu & epidermal growth factor receptor activity
3. Targeted therapy
4. Signal transduction prohibitor

DOSAGE REGIMENS OF Tykerb 

In HER2 positive advanced breast cancer:
The usual dose of Tykerb is 1250mg should be given orally as a single dose on day 1 to 21 repeatedly concomitant with Capecitabine 2000mg/m2/day (administer 2 doses relatively 12 hours apart orally ) on day 1 to 14 in a continuous 21-day cycle. Sum of 5 tablets of Tykerb should be given at a time as a whole.
Patients with hormone receptor-positive HER 2 positive advanced breast cancer:
The usual dose is 1500mg should be given orally as a single dose by combination with letrozole. The usual dose of letrozole is 2.5mg as a once-daily Administer 6 tablets of Tykerb in this condition

PHARMACOKINETICS

Chemically Tykerb 250mg is classify as 4-anilinoquinazoline derivative, that evacuates anti-cancer activity by inhibiting intracellular tyrosine kinase domains of EFGR & HER type 2. The ErbB forced cancer cell production has been prevented by Lapatinib. This growth factor receptor present on cell surface of cancer mass which may lead to cause cell death.
Absorption:
incomplete and insufficient absorption, the time to peak plasma concentration is 4 hours after intake of drug.

Distribution:

The drug bounds to human plasma protein like albumin & alpha glycoprotein relatively 99%.
Metabolism:
Tykerb is a substrate of P-gp & BCRP and go through intensive metabolism by using CYPP3A4 & CYP3A5 with minimum contribution of CYP2C19 & CYP2C8.
Excretion:
Elimination occurs via feces & urine Half lifetime in 14.2 hours reaches by single dose of Tykerb 250mg and multiple dosing reaches in 24 hours.

PRECAUTION

Reduction in left ventricular ejection fraction: While using Tykerb 250mg in a patient with LVEF Caution should be taken The resentment of LVEF should be decreased within first 12 weeks of treatment Before starting the therapy with Tykerb, a patient must be monitor thoroughly if suspected with LVEF or not.
Liver damage : Raising level of AST, ALT or bilirubin may cause liver injury To inhibits this condition, periodic LFT should be control
Diarrhea : Serious diarrhea may cause to dehydration leads death also; if patient do not recover from this severity must stop with this therapy. Interstitial lung disease: Patient should be check with pulmonary symptoms and give supportive measures. On Serious condition, treatment should be discontinue
QT prolongation : Balance ECG periodically Give the patient substituent for this adverse condition Hypokalemia and hypomagnesemia correction should take place Cutaneous reactions: Some life threatening reactions may occur, in this condition therapy should be discontinued
Embryo fetal damage : Tykerb leads to fetal damage and produce some deformities. During therapy Patient should advice not getting pregnant.

Dose alteration :

Cardiac events: Left ventricular ejection fraction with grade 2 reduction in patients is given treatment with Tykerb  250mg should be discontinued. In this condition, the dose of Tykerb should be started with 1000mg/day in combining with Capecitabine; whereas in combination with letrozole the dose of Tykerb restated with 1250mg/day after 2 weeks, if LVEF turns to normal.

DRUG INTERACTION

The drug Tykerb 250mg are prohibition of CYP3A4, CYP2C8 & P-gp drug transporters; weak inhibitor of CYP3A4. Interaction of Midazolam with Tykerb, increases the exposure of Midazolam Interaction of Paclitaxel will Increase in paclitaxel exposure occurs while concomitant with Tykerb Digoxin interaction with Tykerb 250mg then the Serum digoxin concentration should be examined periodically prior starting the concomitant use Drug that induce or inhibit CYP3A4 enzymes: If the interaction of Tykerb tablets with CYP3A4 inducers or inhibitors, alteration of dose is necessary. Interaction of Ketaconazole with Tykerb, the dose reduced to 200mg as two times a day for 7 days. Interaction of Carbamazepine with Tykerb, the dose of carbamazepine at 100mg as a two times a day for 3 days & 200mg for two times a day for 17 days, the exposure of Tykerb reduced to 72%. Concomitant use of Tykerb with P-gp inhibitors causes increasing the concentration of Lapatinib

OVERDOSAGE

The doses of Tykerb 250mg tablet range from 2500mg to 9000mg daily, the duration of therapy should be varied between 1 & 17 days.Symptoms occurred during over dose of Tykerb are;Sore scalp, sinus tachycardia & mucosal inflammation. Patients should be providing supportive measures.
Hepatic impairment

Severe hepatic impairment in patients, the dose reduced from 1250mg/day to 750mg/day or from 1500mg/day to 1000mg/day. Administer the Tykerb tablet without food as 1 hour before or 2 hours after the uptake of food. Administration of capecitabine along with food or given within 30 minutes after food ingestion.

TYKERB SIDE EFFECTS

Stomatitis, Dyspepsia, Diarrhea, Nausea, Vomiting, Liver toxicity, Interstitial lung disease, Anaphylactic reactions, Stevens Johnson syndrome, Ventricular arrhythmias, QT prolongation, Palmar plantar erythrodysaesthesia, Rash, Dry skin, Mucosal inflammation, Musculoskeletal pain in extremity, Back pain, Dyspnea, Insomnia, Alopecia, Pruritus, Nail disorders, Asthenia, Headache, Epistaxis, Elevation of hemoglobulin, platelets, neutrophils, Increase in AST & ALT, bilirubin, Reduction of left ventricular ejection fraction.

PREGNANCY

Pregnancy category: D Tykerb 250mg tablet should not be recommended during pregnancy condition.

Tykerb 250mg

CONTRAINDICATION

The patients who are contraindicated to the component present in Tykerb tablet then hypersentivity reaction occurs

MISSED DOSE

If missed a dose the have it as soon possible or Missed dose should be swapped and continue the regular dosing schedule for avoiding adverse conditions. If missed dose occurs, it should not be resumed and continue the next schedule.
STORAGE

Store the drug at 25℃ (77℉).  Protect free from moisture, heat or light

Contact Details

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